Taken together, the finding of recruitment of GABAergic, glutamatergic and dopaminergic signaling by the NRG1-ErbB4 pathway provides a biologically plausible mechanism that is consistent with its genetic association (see above) and consolidates many hypotheses on the involvement of different neurotransmitter systems in the etiology of schizophrenia (reviewed in [3]). The gene discussed is ERBB4; the disease is schizophrenia.