These antiangiogenic drugs that disrupt VEGF signaling, induce a transient functional normalization of the tumor vasculature (immature vessels are pruned, blood vessel tortuosity decreases, and a closer association between pericytes and endothelial cells is induced) that can improve the activity of coadministered chemotherapies or the effect of radiation therapy [47], [48]. The gene discussed is VEGFA; the disease is neoplasm.