Moreover, the colorectal carcinogenesis role of ADIPOQ rs1063538 was modified by environmental factors such as smoking status, family history of cancer, alcohol use and BMI, and the combined effect of multiple potential factors, including smoking, ADIPOQ rs1063538, BMI and ADIPOR1 rs1539355, showed a significant dosage effect in a gene-environment interaction approach. Here, ADIPOQ is linked to cancer.