Previously studies have documented that ADIPOQ repressed colon cancer cell lines (including HCT116, HT29 and LoVo) proliferation via ADIPOR1- and -R2-mediated AMPK, whereas, knockdown of ADIPORs such as ADIPOR1 relieved the suppressive effect of ADIPOQ on the growth of cancer cells [19]. This evidence concerns the gene ADIPOQ and malignant colon neoplasm.