Meanwhile, the observation of an ecologic correlation between adipokines secretion disorders and metabolic syndrome traits, has spawned a number of epidemiological studies of the association between important adipokines, especially between adiponectin (ADIPOQ) and its receptors (ADIPORs) with obesity and insulin resistance, which showed that circulating ADIPOQ level was significantly negatively, whereas ADIPORs level was positively, associated with metabolic syndrome traits [11], [12]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.