After matching 42 pairs remained available for a supplementary analysis: In these matched pairs of alcoholic patients with and without hepatocellular carcinoma the PNPLA3 148M allele frequencies were 53.6% vs. 31.0% (OR = 2.57; 95%-CI: 1.37–4.84; p = 0.003), respectively. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.