Of note, the distribution of PNPLA3 I148M alleles was similar in healthy controls and patients with HCV-associated cirrhosis and HCV-related HCC giving rise to 22.9%, 25.3% (p = 0.545) and 30.2% (p = 0.071) frequencies of the 148M allele, respectively. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.