Accordingly, PGC-1α levels are reduced in the heart following MI by coronary artery ligation in rats [14] while treatment with angiotensin II receptor blockers (ARB) and PPAR agonists (pioglitazone and rosiglitazone), preserve both ventricular function and PGC-1α levels, and have been demonstrated to attenuate myocardial ischemia-reperfusion injury [15], [16], [17]. This evidence concerns the gene PPARGC1A and myocardial infarction.