In the present study we combined the anti-EGFR antibody (Clone 225) as a molecular therapeutic with hybrid plasmonic magnetic NPs and studied the molecular interactions between EGFR-targeted NP (225-NP) in the size range of 40–50 nm and human non-small cell lung cancer (NSCLC) cells. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.