PSMA6 and metabolic dysfunction-associated steatotic liver disease: The major etiologies of HCC are well defined including: Chronic viral hepatitis B, C, and D; Toxins and drugs (e.g, alcohol, aflatoxins, anabolic steroids); Metabolic liver diseases (e.g., hereditary hemochromatosis, alpha-1-antitrypsin deficiency); Diabetes mellitus, obesity in men, nonalcoholic fatty liver disease (NAFLD).