However, our study found, at the time of GH initiation, for no obvious reason, a much higher prevalence of associated hormone deficiencies in the ONH/SOD group compared to the data reported in the NCGS study (hypothyroidism: 63.2% vs 27%, glucocorticoid deficiency: 52.2% vs 24%, and diabetes insipidus: 12.9% vs 5%) [4]. Here, SOD1 is linked to familial glucocorticoid deficiency.