In addition to the aforementioned factors, which affect the general population, we could question how much nutritional habits and iodine sufficiency influence the occurrence of other neoplasias, specifically in patients with DTD treated by 131I. The uptake of iodine by the thyroid tissue is mediated by sodium-iodide symporter (NIS), cloned in 1996 [27]. The gene discussed is SLC5A5; the disease is neoplasm.