Based on the binding properties of HN-1 to HNSCC cells (binding exclusively to adherent culture of polarized cells), an HN-1 similar protein, hemicentin (fibulin-6), has been further investigated: TSPLNIHNGQKL is the HN-1 sequence, where the bold labeled amino acids of HN-1 are identical with hemicentin. The gene discussed is HMCN1; the disease is head and neck squamous cell carcinoma.