TNF and infection: In the British Society for Rheumatology Biologics Register, overall serious infection rates during anti-TNF therapy compared with DMARD treatment were not increased (IRR 1.03, 95% CI 0.68–1.57), but in contrast anti-TNF therapy increased the rate of serious skin and soft tissue infections (IRR of 4.28, 95% CI 1.06–17.17) [14].