In the Spanish biologicals register BIOBADASER, annual TB incidence rates of 1893 and 1113 per 100 000 were reported in the year 2000 and 2001 respectively, in anti-TNF treated RA patients, in comparison with 95/100 000 in RA patients not treated with TNF inhibitors and 20/100 000 in the general population [50,51]. Here, TNF is linked to tuberculosis.