NPM1 and acute myeloid leukemia: More recently, Sarry et al. have observed that a high engraftment level occurred within human primary AML samples carrying at least two mutations (seven out of nine samples had FLT3-ITD and NPM1 mutations) and that these mutations were strongly conserved in the different leukemic stem cell populations sorted as well as still present after the first transplantation into NOD/SCID-IL2Rγc−/− mice [18].