The results indicate that the up-regulated genes in metastatic cancer cells are enriched in extracellular matrix (ECM) receptor interaction, focal adhesion, and angiogenesis, while down-regulated genes are enriched in genes functioning in immune and inflammatory response (Table 4), and these include laminin, fibronectin, collagen, multimerin, caveolin, etc.. The gene discussed is FN1; the disease is cancer.