Even so, only a single known gene was predicted by CMP seeded, TCF2 for the T2D phenotype which shares hepatocyte nuclear factor 1 domains HNF-1B_C (PF04812) and HNF-1_N (PF04814) with known disease gene TCF1. CMP ab initio predicted CARD15/NOD2 for the CD phenotype, but other predictions did not pass the required thresholds. Here, NOD2 is linked to type 2 diabetes mellitus.