We report herein i) that NGF, BDNF, TrkB, p75NTR and its co-receptor sortilin were expressed in two DLBCL cell lines and ii) that their responsiveness to rituximab was depending on NT secretion and TrkA expression suggesting a relationship between Trk signaling and rituximab sensitivity. Here, NTRK1 is linked to diffuse large B-cell lymphoma.