Skeletal muscle is a primary site of insulin resistance in essential hypertension [29], [30] It is interesting to note that SHR exhibit several skeletal muscle abnormalities and dysfunctions when compared to WKY counterparts including decreased fatigue resistance [31], insulin resistance [32], development of less contractile force [33], increased interstitial norepinephrine levels [34], altered sodium pump number and activity [35], elevated intracellular free calcium [36], fiber type transformation [37], and decreased capillary density [38]. This evidence concerns the gene ATP12A and hypertensive disorder.