PTEN and endometrial cancer: Lian et al (2006) studied PTEN activity in endometrial cancer and found deregulated expression of INMT associated with PTEN loss. In another study into non-small cell lung cancer (NSCLC), decreased expression of INMT was associated with cancerous tissue when compared with normal lung (Kopantzev et al, 2008). Similarly, qPCR data from this study found decreased expression of INMT in the more aggressive PCa cases. The implication of the downregulation of INMT in association with the progression of PCa is unclear.