When the cells were treated with CIS, we observed 1.3 to 3 fold up-regulation of P53, P16, BAX, BAD, BAK, NOXA, CASPASES-3, -9, IκBα, P65/RELA, BCL-XL and MCL-1, P21 and PUMA. Here, BAK1 is linked to in situ carcinoma.