Finally, in CIS-treated HaCaT cells, we found 1.3- to 3-fold up-regulation in CASPASES-3, -9, BAX, BAD, NOXA, P16 and MCL-1 and one of > 5-fold in P65, P53, PUMA, BAK, P21 and BCL-XL. Here, BBC3 is linked to in situ carcinoma.