In general, we observed in HeLa and SiHa cervix cancer cells an up-regulation of some proapoptotic genes after PTX + CIS treatment, including the DIABLO, NOXA, PUMA, CASPASES-3 and -9 genes, which are implicated in the mitochondrial pathway of apoptosis [43]. The gene discussed is PMAIP1; the disease is in situ carcinoma.