TP53 and in situ carcinoma: In PTX + CIS treated HeLa cells we observed 1.3 to 3 fold up-regulation of IκBα, P65/RELA, P53, BAK, BAX, BAD, P16 and MCL-1 up-regulation of > 3-fold in CASPASES-3, -9, NOXA and P21.