CASP8 and in situ carcinoma: In Figure 1C, it can observe that untreated group of HeLa and SiHa cells displayed minimal caspase-8 activity, but when these cells were treated with PTX, we found increments of caspase-8 activity to be 4.2 and 2.7 fold higher in HeLa and SiHa cells, respectively (P <0.001 vs untreated cells), also CIS alone induces an increase of caspase-8 activity but lower that the increment induced by PTX (HeLa 1.71 and SiHa 1.9 times higher than corresponding untreated cells).