FLT1 and preeclampsia: Furthermore, it was recently reported that both in normal and preeclamptic pregnancies, smoking is associated with lower maternal plasma concentrations of soluble fms-like tyrosine kinase-1 (sFlt-1) [7], a circulating anti-angiogenic protein that induces endothelial dysfunction and is found in higher concentrations in pregnant women who subsequently develop preeclampsia [8].