Diverse studies have proposed an important role of the APOE in hypercholesterolemia and statin response based in this association with APOE ε2/ε3/ε4 genotypes, but little information is known about the relationship of these variables with the expression status of APOE. Here, we describe the mRNA expression profile in PBMC from NL individuals and HC patients treated with atorvastatin. This evidence concerns the gene APOE and Hypercholesterolemia.