The gene encoding the apoE protein (APOE) is polymorphic resulting in three major isoforms (ε2, ε3 and ε4) caused by two single nucleotide polymorphisms (SNPs) in the exon 4 of the APOE, resulting in cysteine-arginine interchanges at residuals 112 and 158 of the protein, which has been associated with a number of pathophysiological conditions, including cardiovascular and neurological diseases [3]. The gene discussed is APOE; the disease is nervous system disorder.