Most striking are data demonstrating that the lipid chelator 2-hydroxypropyl-β-cyclodextrin (CD) partially can replace the function of NPC1 and NPC2 proteins [32], diminishes neuropathy, delays motor deficits, and increase median survival in both NPC1−/− and NPC2−/− mice [13], [14], [33], [34]. This evidence concerns the gene NPC1 and neuropathy.