Since the minor allele at -250G/A LIPC is associated with a decrease in HL activity and a reduction of TG catabolism from HDL and LDL and the TG content in HDL and LDL is, to a certain extent, the result of an increased CETP activity associated to the B1B1 genotype, we propose that the presence of the A allele of -250G/A LIPC reduced the risk of T2D among B1B1 Taq1B CETP genotype carriers, although the LIPC polymorphism was by itself not associated with T2D. The gene discussed is LIPC; the disease is type 2 diabetes mellitus.