LIPC and hypertriglyceridemia: We suggest that while the risk of T2D associated to the B1B1 CETP genotype is a consequence of hypertriglyceridaemia by the increase of the flux of FFAs from HDL and LDL particles to the liver, a decrease activity of HL associated to -250 A LIPC allele reduces that flux of FFAs, and the risk of T2D amongst B1B1 carriers.