Realtime PCR validated the presence of the GALC deletion, but not the CNV calls in the regions of RASA4, EYA1, CROCC, or ALDH1A2. In the discovery dataset, 2/71 (2.8%) POAG cases were identified with heterozygous deletions in GALC while none were found in 478 age-matched US Caucasian controls (Figure 1). Here, RASA4 is linked to open-angle glaucoma.