The beneficial action of euphol in ameliorating colitis seems likely associated with its ability to prevent the expression of pro-inflammatory mediators and/or release in colonic tissue through inhibiting leukocyte influx (mainly neutrophils and macrophages) into inflammatory foci by blocking adhesion molecule expression, such as selectins (P- and E-selectins) and integrins (ICAM-1, VCAM-1 and LFA-1), without compromising the integrity of the endothelial barrier. Here, ITGAL is linked to colitis.