Treatment of osteosarcoma (OSA) and mast cell tumor (MCT) cell lines with either ganetespib or STA-1474 induced growth inhibition, apoptosis that was caspase3/7 dependent, and inactivation and/or down-regulation of pKit/Kit, pMet/Met, pAkt/Akt, and pSTAT3. The gene discussed is AKT1; the disease is obstructive sleep apnea syndrome.