Ischemia/reperfusion injuries were associated with mitochondrial collapse, as revealed by the significant 35% decrease in the mitochondrial/cytosolic cytochrome c ratio in the ninety minutes' ischemia control group versus the sham-operated group (P<0.001).The decrease in the mitochondrial/cytosolic ratio was reduced by IP (24%), IC (16%) and mangafodipir (9%) versus the ninety minutes' ischemia control group (P<0.001, 0.001 and 0.01, respectively) (Fig 5A). The gene discussed is CYCS; the disease is ischemia.