Previous studies have suggested that neurons harboring GVDs with phosphorylated tau accumulation reflected ‘toxic’ or ‘apoptotic’ alterations in AD [11], [18], based on their relationship with phosphorylated tau, whose degree of accumulation correlates with neuronal loss in the hippocampus [42], [48], [49], as well as the hippocampal vulnerability, both of which have been extensively characterized and documented in AD [50]. This evidence concerns the gene MAPT and Alzheimer disease.