Here, we show that systemic administration of IL-4 treated bone marrow-derived myeloid cells (BMDM) to G93A mutant superoxide dismutase-1 (mSOD1) mice (ALS mice) before emergence of disease symptoms resulted in earlier appearance of disease symptoms and shorter life expectancy, while the same protocol mitigated the inflammation-induced disease model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). The gene discussed is IL4; the disease is multiple sclerosis.