Because sense strand mAPC exhibited significantly higher specificity as a biomarker for HCC when a cutoff value was applied and mAPC was detected in the blood of patients with HCC, suggesting it as a potential circulating DNA marker for HCC screening [36], [37], we compared sense mAPC with the current accepted biomarker for HCC screening, the serum AFP level. This evidence concerns the gene AFP and hepatocellular carcinoma.