APC and hepatocellular carcinoma: Interestingly, we did not find a significantly higher incidence of mAPC in HBV-infected HCC than non-HBV-infected HCC in this study, nor in HCV-infected HCC, although it has been suggested that HBV or HCV infection increases the aberrant methylation of tumor suppressor genes in HCC, including the APC gene [32], [46].