EIF2B5 and leukoencephalopathy with vanishing white matter: Childhood Ataxia with Central nervous system Hypomyelination (CACH), also known as Vanishing White Matter disease (VWM), is an autosomal recessive genetic leukodystrophy associated with mutations in any one of the five subunits of eukaryotic translation initiation factor 2B (eIF2B) [1], [2].