GADD45A and neoplasm: In the subsequent study, Satomi and Nishino [77] showed that several MAPKs modulated the induction of GADD45 and G1 arrest, and positive regulation by SAPK/JNK was involved in GADD45A induction and G1 arrest by fucoxanthin, indicating that GADD45A was closely related with the G1 arrest induced by fucoxanthin, and MAPK pathways were implicated in fucoxanthin-induced GADD45A expression and G1 cell cycle arrest in tumor cells depending on the cell type.