Gene ontology (GO) analysis of genes that were changed more than 2-fold in DSCAM-expressing versus parental cells (p<0.0005) identified genes involved in cellular adhesion (GO terms: ECM-Receptor interaction and focal adhesion - Figure 4b) and cardiomyopathies (GO: hypertrophic cardiomyopathy, cardiac hypertrophy, fibrosis - Figure 4c and Table S5), which is consistent with the prominent cardiac hypertrophy we observed in double transgenic animals expressing DSCAM and COL6A2 (Figure 4b and Table S4). The gene discussed is COL6A2; the disease is cardiac hypertrophy.