Prx IV is decreased in stomach cancers [101]; may play an important role in protecting cells from ionizing radiation-induced apoptosis in head-and-neck squamous cell carcinoma [102]; in lung cancer cells, Prx IV interacts with surfiredoxin and the interaction axis leads to acceleration of tumor growth and metastasis formation in vivo [103]. This evidence concerns the gene PRDX4 and gastric neoplasm.