SOD2 and pheochromocytoma: In a study by Keller et al. [188], overexpression of MnSOD protects PC6 pheochromocytoma cells from apoptosis induced by Fe(II), amyloid β-peptide, and NO generating agents by inhibiting peroxynitrite production and lipid peroxidation, as well as prevents mitochondrial transmembrane potential collapse and a decrease in mitochondrial activity caused by these agents.