Khaper et al. followed the expression of various antioxidant enzymes, including MnSOD, at different times following myocardial infarction in rats, and found that MnSOD mRNA levels were reduced early (1 week) and long after (16 weeks) infarction, but MnSOD mRNA was near control levels at 4 weeks post-infarction [356]. This evidence concerns the gene SOD2 and infarction.