Administration of MnSOD plasmid/liposome intraesophageally or intraorally into mice to induce localized overexpression of MnSOD protects the animals from lipid peroxidation induced by ionizing radiation compared to control mice [249].MnSOD may also play a role in lipid peroxidation caused by hypertension. The gene discussed is SOD2; the disease is hypertensive disorder.