SOD2 and hereditary pheochromocytoma-paraganglioma: On the contrary, overexpression of MnSOD in the PC6 pheochromocytoma cell line attenuates lipid peroxidation and the formation 4-HNE-adducted proteins caused by treatment with Fe(II), sodium nitroprusside (a nitric oxide-generating agent), and amyloid β-peptide, as well as lipid peroxidation in vivo caused by local cerebral ischemia [188].