Li et al. generated a strain of mice expressing an enzymatically inactive mutant of MnSOD and identified several cardiovascular abnormalities in homozygous MnSOD knock-out animals, including dilated left ventricular cavity, reduced left ventricular wall thickness, and myocardial hypertrophy resulting in dilated cardiomyopathy [100]. The gene discussed is SOD2; the disease is cardiac hypertrophy.