For example, MnSOD expression is associated with an increase in lymph node metastases of both colorectal [303] and gastric cancer [292], and is important for the metastatic behavior of the estrogen-independent breast cancer cell line MDA-MB-231 [304], as well as progestin-stimulation of migration and invasion in T47D human breast cancer cells [305]. This evidence concerns the gene SOD2 and breast carcinoma.