Because of the importance of MnSOD in protecting different mitochondria-centered metabolic enzymes from ROS-mediated deactivation, the decrease in MnSOD expression and activity associated with cancer, and the fact MnSOD is a target of SIRT3 deacetylase, it is tempting to speculate that MnSOD may be essential for initiation of the Warburg effect in the development and progression of cancer. This evidence concerns the gene SOD2 and cancer.