Although iAUC and Ktrans are incompletely validated endpoints that are sensitive to changes in a number of hemodynamic parameters, including blood flow, blood volume, vessel permeability and vessel surface area [71], emerging data from several early-phase clinical trials of VEGF signaling inhibitors have shown changes in Ktrans and/or iAUC that are consistent with reductions in VEGF-dependent tumor perfusion and vascular permeability [72–74]. This evidence concerns the gene VEGFA and neoplasm.