Swarup et al. [131] found a moderate phenotype expressed by Tg mice driven by the native promoter of human TDP-43, including cognitive impairment and motor coordination with massive cytosolic redistribution of TDP-43, while ALS-linked mutant TDP-43 proteins more readily aggregate in stress granules (SG) than the WT protein [132]. This evidence concerns the gene TARDBP and Cognitive impairment.