SOD1 and amyotrophic lateral sclerosis: However, intensive genetic approaches to familial ALS (FALS) patients have successfully identified diverse ALS-causative genes including SOD1, ALS2, SETX, SPG11, FUS, VAPB, ANG, and TDP-43, which are assigned as ALS1, 2, 4, 5, 6, 8, 9, and 10, respectively [8].