Gruzman et al. [80] showed that aberrantly dimerized SOD1 is a common finding in spinal cord lysates from sporadic and mutant SOD1-linked familial ALS patients, and recently, motor neurons of sporadic ALS patients were labeled by the monoclonal antibody (C4F6), which recognizes misfolded SOD1 protein, but not natively folded WT SOD1 [81]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.