TARDBP and nervous system disorder: Recent attempts to grossly screen TDP-43-associated mRNAs using cross-linking and immunoprecipitation (CLIP) from brains of FTLD patients [90], mice brain with or without ablation of TDP-43 by siRNA [91], and human neuroblastoma cell line SHSY-5Y [92] revealed that huge amounts of RNA that bind TDP-43, which interacts with introns at UG/TG-rich repeat motifs of various mRNAs associated with neuronal development and neurological diseases, including TDP-43 itself and progranulin [90–92].