rs2651899 at 1p36.32 is located within the first intron of PRDM16, rs10166942 at 2q37 is very close to the transcription start site for TRPM8, and rs11172113 at 12q13.3 is in the first intron of LRP1. Interestingly TRPM8 was associated with migraine in the first IHGC GWAS at the sub-genome-wide level [57]. This evidence concerns the gene TRPM8 and migraine disorder.