On two independent Hong Kong HCC cohorts that we previously described [10], the HCC prognosis was significantly associated with clinicopathologic parameters including tumor size, number of tumor nodules (NOTN), tumor stage (new AJCC and pTNM), venous infiltration status, serum albumin level (ALBU), and serum α-fetoprotein level (AFP). The gene discussed is ALB; the disease is hepatocellular carcinoma.