PDGFRA and melanoma: While targeting the PDGFR usually results in inhibition of cell survival [35], similar results to ours have been reported in other models; PDGFRα overexpression was shown to inhibit melanoma tumor cell growth in vitro and in vivo [36], while overexpression of PDGF-BB in human pancreatic and colorectal cells resulted in a reduction in tumor growth [37].