The univariate analysis revealed that age at disease onset (p < 0.001), skin ulcers (p = 0.01), cardiac involvement (p = 0.11), presence of cancer (p < 0.001) or ILD (p = 0.12), low TP level (p = 0.15), low ALB level (p = 0.02), and elevated IgA at diagnosis (p = 0.08) were likely to be the risk factors for mortality. The gene discussed is ALB; the disease is Skin ulcer.