GUCY2C and colonic neoplasm: In the context, ST conjugated to a radionuclide retains full potency for GC-C binding, and differential accumulation in subcutaneous and hepatic human colon tumors expressing GC-C, but not in other tissues or tumors that do not express GC-C, can be visualized by gamma camera scintigraphy with extremely high sensitivity and specificity [146,147,148,149,150,151,152,153].