Although EAE reflects important pathogenic mechanisms in MS, observations such as a dominance of clonally expanded CD8+ T cells in active MS lesions, the perpetual intrathecal production of oligoclonal IgG, and the failure to firmly establish myelin proteins as target antigens in MS underscore critical differences in the pathogenesis of human MS and animal EAE [61]. Here, CD8A is linked to myeloid sarcoma.