As largely reviewed by others, in these cellular model, curcumin inhibits NF-κB activation, neurotensin-mediated activator protein-1, Ca2+ mobilization, PGE-2 (prostaglandin E2) and epidermal growth factor receptor (EGF-R) and down-regulates COX-1/2, MMP-2/9, IL-8 gene induction and colon cancer cell migration [47,48]. Here, EGFR is linked to malignant colon neoplasm.