VEGFA and neoplasm: (VEGF)-gelonin fusions are able to inhibit tumor growth and metastasis dissemination, and recently, by a fed-batch cultivation method the investigators could achieve high cell densities, comparable to those obtained with the methylotrophic yeast strains (of about 40 OD/mL) with an overall production of a biologically active histidine-tagged VEGF-gelonin fusion in AD494 pLysS of 42.5 mg/L (compared to 1.6 mg/L produced using conventional flask cultivation methods) [159].