WNK2 and neoplasm: Tumor histology and in vivo angiogenesis assays suggested that these effects can be attributed to indirect targeting of tumor vasculature and angiogenic processes (expression of MMPs has been shown to be upregulated in angiogenic lesions [486,487,488,489]), in which mitogen-activated protein kinase (MAPK) signaling pathways play a central role [422,490].