The order of binding potency for dd recombinant proteins to α4β1-mediated MOLT 4 (human acute lymphoblastic leukemia cell line containing α4β1) cell is demonstrated to be dd(2)-ADAM-15 > dd(19)-ADAM-15 > dd(den)-ADAM-15 = ddADAM-15 > dd(12)-ADAM-15 while dd(A64)-ddADAM-15 showed little/no ability to support cell adhesion compared to its wild-type counterpart. This evidence concerns the gene ADAM15 and acute lymphoblastic leukemia.