These observations clearly illustrate that the crosstalk between pro- and anti-apoptotic PKC isoforms is important, and the final effect of the PKC-agonist PEP005 may therefore depend upon the balance between the various isoenzymes present within a tumor and the drug may be less effective in those tumors with increased levels of the anti-apoptotic isoforms (Table 2). The gene discussed is PRRT2; the disease is neoplasm.