Furthermore, curcumin is able to potentiate the antiproliferative effect of 5-FU associated with oxaliplatin or oxoplatin alone and to stimulate cell death by apoptosis through the attenuation of epidermal growth factors (EGF) and insuline-like growth factor (IGF) signaling pathways in colon cancer HCT-116 and HT-29 cells [209,210]. Here, EGF is linked to colonic neoplasm.