More recently, curcumin was also found to potentiate the anti-tumor effect of gemcitabine, another pyrimidine antimetabolite, by suppressing proliferative and angiogenic biomarkers and by modulating the NF-κB signaling pathway in vitro in human bladder cancer 253JBV cells and in vivo in an orthotopic human bladder cancer [134]. This evidence concerns the gene NFKB1 and urinary bladder carcinoma.