CYCS and neoplasm: This leads to the opening of mitochondrial permeability transition pores, the release of cytochrome c, the activation of the apoptosome (caspase-9/apaf-1/cytochrome c) and the subsequent cleavage of caspase-3, -6 and -7, Poly (ADP-ribose) polymerase (PARP) and finally to the death of tumor cells [169,170,171].