Activin A has also been described to regulate stemness [17] and we hypothesized that CD44 as a stem cell marker might be under the regulation of Activin A. To identify a potential signaling pathway responsible for the upregulation of CD44, we analyzed the esophageal cancer cell line, TE-11, after knockdown of E-cadherin using siRNA. The gene discussed is CDH1; the disease is esophageal cancer.