Previous studies have demonstrated that several adhesion molecules and chemokines, including CXCR4, CD56, CD44, CCR7, and VLA-4, contribute to the harboring and proliferation of leukemic cells in the BM niche and may enhance niche-mediated resistance in leukemia [21], [22], [23], [24], [25]. The gene discussed is CD44; the disease is leukemia.